Anti-ACE2 antibody produced in rabbit
SIGMA/SAB3500978 - affinity isolated antibody
Synonym: Anti-ACEH
Product Type: Chemical
Immunohistochemistry Immunohistochemical staining of human kidney cells using ACE2 antibody at 2 μg/mL.
Immunofluorescence Immunofluorescence of ACE2 in Human Kidney cells with ACE2 antibody at 10 μg/mL.
Immunoblotting ACE2 Antibody: Cat. No. SAB3500978: Western blot analysis of ACE2 in Human kidney lysate with ACE2 antibody at 1 μg/mL.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| NCBI accession no. | NP_068576   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: suitable |
| immunoblotting: suitable | |
| immunofluorescence: suitable | |
| immunohistochemistry: suitable | |
| UniProt accession no. | Q9BYF1 |
| Biochem/physiol Actions: | Angiotensin-converting enzyme-2 (ACE2) aids in maturation of angiotensin (Ang) by converting Ang I to Ang1-9. It may also play a role in the local renin-angiotensin system (RAS) in heart and kidney. Ace 2 serves as a functional receptor for severe acute respiratory syndrome–coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2), which is responsible for causing coronavirus disease 2019 (COVID-19). Reduced expression of Ace 2 might cause cardiovascular diseases. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Angiotensin-converting enzyme-2 (ACE2) gene is mapped to human chromosome Xp22.2. The gene codes for a membrane-associated and secreted enzyme. Ace 2 is a human homolog of angiotensin-converting enzyme (ACE) and is found mainly on endothelium. In humans, Ace2 is exclusively expressed in heart, kidney, and testis. The protein is characterized with an N-terminal PD and a C-terminal collectrin-like domain (CLD). |
| Immunogen: | Antibody was raised against a synthetic peptide corresponding to amino acids near the N terminus of human ACE2. |
| Other Notes: | The action of this antibody can be blocked using blocking peptide SBP3500978 . |
| Physical form: | Supplied at 1 mg/mL in PBS with 0.02% sodim azide. |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |