Anti-S-100 (β-Subunit) antibody, Mouse monoclonal
SIGMA/SAB4200671 - clone SH-B1, purified from hybridoma cell culture
Synonym: Monoclonal Anti-S-100 (β-Subunit) antibody produced in mouse; NEF; S100; S100-B; S100beta
Product Type: Chemical
Immunohistochemistry Staining of formalin-fixed, paraffin-embedded rabbit tongue sections with 1.5 μg/mL Monoclonal Anti S-100 (b-Subunit) , Clone: SH-B1 (Cat. No.SAB4200671), using biotin/ExtrAvidin®-Peroxidase
| antibody form | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | SH-B1, monoclonal |
| concentration | ~1 mg/mL |
| isotype | IgG1 |
| Quality Level | 200  |
| shipped in | dry ice |
| species reactivity | cat, rabbit, porcine, bovine, rat, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: 1.5-3 μg/mL using immunoperoxidase labeling of pronase digested, formalin-fixed, paraffin-embedded sections of rabbit tongue. |
| Application: | Monoclonal Anti-S-100 (β-Subunit) antibody produced in mouse has been used in: • immunohistochemistry • enzyme linked immunosorbent assay (ELISA) (Ca2+ ion independent) • immunocytochemistry • immunoblotting • dot blot • immunohistochemistry. |
| Biochem/physiol Actions: | S-100 is involved in cell-growth regulation, increasing membrane permeability to cations, inflammatory response in many brain diseases, including schizophrenia, stimulation of nucleolar RNA polymerase activity and transporting proteins and free fatty acids in adipocytes. S-100β tissue distribution can be a useful tool in the differential diagnosis of neoplasms and proliferative processes. |
| Biochem/physiol Actions: | S-100β protein interacts with synaptic, cytoskeletal and cell cycle proteins. Additionally, it can regulate calcium levels in glial and neuronal cells. It is involved in neuronal plasticity, astrogliosis and neuronal cell survival. S-100β is associated with Alzheimer disease and amyotrophic lateral sclerosis. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| General description: | Monoclonal Anti-S-100 (β-subunit) (mouse IgG1 isotype) is derived from the SH-B1 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. S-100 is a set of small, thermolabile, highly acidic homo or hetero-dimer calcium binding proteins. The protein exists in two isoforms namely, S-100α and S-100β, which are brain specific. |
| General description: | S-100β is a calcium binding protein. It is mainly present in astrocytes and neurons of hindbrain and spinal cord. |
| Immunogen: | Purified bovine brain S-100β |
| RIDADR | NONH for all modes of transport |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |