Anti-phospho-GATA1 (pSer310) antibody produced in rabbit
SIGMA/SAB4300031 - affinity isolated antibody
Synonym: Anti-ERYF1 antibody produced in rabbit; Anti-GATA binding protein 1 (globin transcription factor 1) antibody produced in rabbit; Anti-GF-1 antibody produced in rabbit; Anti-GF1 antibody produced in rabbit; Anti-NFE1 antibody produced in rabbit
MDL Number: MFCD02096392
Product Type: Chemical
Immunofluorescence Anti-phospho-GATA1 (pSer310): SAB4300031: Staining of methanol-fixed HeLa cells using Anti-phospho-GATA1 (pSer310) antibody (Red).
Immunoblotting Anti-phospho-GATA1 (pSer310): SAB4300031: Analysis of extracts from HT29 cells untreated or treated with Anisomycin using Anti-phospho-GATA1 (pSer310) antibody.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (K-A-SP-G-K) |
| isotype | IgG |
| mol wt | ~43 kDa |
| NCBI accession no. | NP_002040.1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, mouse, human |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer310) |
| technique(s) | indirect immunofluorescence: 1:100-1:200 |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P15976 |
| Biochem/physiol Actions: | GATA binding protein 1 (GATA1) plays a crucial role in erythroid and megakaryocyte differentiation and proliferation. It modulates the expression of genes and acts as an E-cadherin repressor. Mutations in the GATA1 gene have been linked to transient abnormal myelopoiesis (TAM) and myeloid leukemia of DS (ML-DS). The protein has anti-apoptotic functions in breast cancer. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
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| General description: | GATA binding protein 1 (GATA1) is a key hematopoietic transcription factor. It is encoded by the gene mapped to human chromosome Xp11.23 and it belongs to the GATA transcription factor family. |
| General description: | GATA1 encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. |
| Immunogen: | Peptide sequence around phosphorylation site of serine 310 (K-A-S(p)-G-K), according to the protein GATA1. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |