Anti-phospho-STAT1 (pTyr701) antibody produced in rabbit
SIGMA/SAB4300032 - affinity isolated antibody
Synonym: Anti-DKFZp686B04100 antibody produced in rabbit; Anti-ISGF-3 antibody produced in rabbit; Anti-STAT91 antibody produced in rabbit; Anti-signal transducer and activator of transcription 1, 91kDa antibody produced in rabbit
MDL Number: MFCD01633987
Product Type: Chemical
Immunohistochemistry Anti-phospho-STAT1 (pTyr701): SAB4300032: Analysis of paraffin-embedded human breast carcinoma tissue using Anti-phospho-STAT1 (pTyr701) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunoblotting Anti-phospho-STAT1 (pTyr701): SAB4300032: Analysis of extracts from HeLa cells untreated or treated with IFN using Anti-phospho-STAT1 (pTyr701) antibody.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (T-G-YP-I-K) |
| isotype | IgG |
| mol wt | ~91 kDa |
| NCBI accession no. | NP_009330.1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, mouse |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr701) |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P42224 |
| Biochem/physiol Actions: | Signal transducer and activator of transcription 1 (STAT1) plays a vital role in interferon (IFN) signaling. Phospho-STAT1 regulates pro- and anti-apoptotic genes following several stress-induced responses. It interacts with p53 and promotes p53-mediated transcriptional gene activity and apoptosis. STAT1 is also an essential factor of stress-induced and DNA damage-induced checkpoint pathways and thus, acts as a tumor suppressor. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Signal transducer and activator of transcription 1 (STAT1) gene is mapped to human chromosome 2q32.2. It is part of the STAT family of proteins. STAT1 exists in two isoforms, STAT1α and STAT1β with molecular weight of 91kDa and 84kDa, respectively. The protein shows ubiquitous expression. |
| Immunogen: | Peptide sequence around phosphorylation site of tyrosine 701 (T-G-Y(p)-I-K), according to the protein STAT1. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |