Anti-phospho-CREB1 (pSer133) antibody produced in rabbit
SIGMA/SAB4300040 - affinity isolated antibody
Synonym: Anti-CREB antibody produced in rabbit; Anti-MGC9284 antibody produced in rabbit; Anti-cAMP responsive element binding protein 1 antibody produced in rabbit
MDL Number: MFCD01092316
Product Type: Chemical
Immunohistochemistry Anti-phospho-CREB1 (pSer133): SAB4300040: Analysis of paraffin-embedded human breast carcinoma tissue using Anti-phospho-CREB1 (pSer133) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunoblotting Anti-phospho-CREB1 (pSer133): SAB4300040: Analysis of extracts from HeLa cells untreated or treated with UV using Anti-phospho-CREB1 (pSer133) antibody.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (R-P-SP-Y-R) |
| isotype | IgG |
| mol wt | ~43 kDa |
| NCBI accession no. | NP_004370.1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, human, rat |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer133) |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P16220 |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
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| General description: | CREB1 is a transcription factor that is a member of the bZIP family of DNA binding proteins. It binds as a homodimer to the CRE (cAMP-Responsive Element), an octameric palindrome containing a conserved core sequence, 5-prime-TGACG-3-prime. It consists of two transcript variants encoding respective isoforms produced by alternate splicing. It is mapped to 2q32.3-q34 . It is phosphorylated by several protein kinases and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB1 is crucial for the consolidation of long-term conditioned fear memories, but not for encoding, storage, or retrieval of these memories. It is required for the stability of reactivated or retrieved conditioned fear memories . |
| Immunogen: | Peptide sequence around phosphorylation site of serine 133 (R-P-S(p)-Y-R), according to the protein CREB1. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |