Anti-phospho-IGF1R (pTyr1165/pTyr1166) antibody produced in rabbit
SIGMA/SAB4300069 - affinity isolated antibody
Synonym: Anti-CD221 antibody produced in rabbit; Anti-IGFIR antibody produced in rabbit; Anti-JTK13 antibody produced in rabbit; Anti-MGC142170 antibody produced in rabbit; Anti-insulin-like growth factor 1 receptor antibody produced in rabbit
MDL Number: MFCD00282340
Product Type: Chemical
Immunofluorescence Anti-phospho-IGF1R (pTyr1165/pTyr1166): SAB4300069: Staining of methanol-fixed MCF cells using Anti-phospho-IGF1R (pTyr1165/pTyr1166) antibody (Red).
Immunoblotting Anti-phospho-IGF1R (pTyr1165/pTyr1166): SAB4300069: Analysis of extracts from 293 cells using Anti-phospho-IGF1R (pTyr1165/pTyr1166) antibody (Lane 2) and the same antibody preincubated with blocking peptide (Lane1).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (T-D-YP-YP-R-K) |
| isotype | IgG |
| mol wt | ~200 kDa |
| ~95 kDa | |
| NCBI accession no. | NP_000866.1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, mouse, human |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr1165/pTyr1166) |
| technique(s) | indirect immunofluorescence: 1:100-1:200 |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P08069 |
| Biochem/physiol Actions: | Insulin like growth factor 1 receptor (IGF1R) on binding to its ligand, IGF2 regulates cell proliferation and growth. The encoded protein is also facilitates the normal embryonic and postnatal growth. It plays a crucial role in the embryonic growth. Mutations in IGF2 are associated with Silver–Russell syndrome and ring chromosome 15 syndrome. It is upregulated in ovarian cancer. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Insulin like growth factor 1 receptor (IGF1R) is encoded by the gene mapped to human chromosome 15q25- qter. The encoded protein is a transmembrane heterotetramer. It is structurally similar to insulin receptor. |
| General description: | This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. |
| Immunogen: | Peptide sequence around phosphorylation site of tyrosine 1165/tyrosine 1166 (T-D-Y(p)-Y(p)-R-K), according to the protein IGF1R. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |