Anti-phospho-MAPT (pSer396) antibody produced in rabbit
SIGMA/SAB4300081 - affinity isolated antibody
Synonym: Anti-DDPAC antibody produced in rabbit; Anti-FLJ31424 antibody produced in rabbit; Anti-FTDP-17 antibody produced in rabbit; Anti-MAPTL antibody produced in rabbit; Anti-
Product Type: Chemical
Immunohistochemistry Anti-phospho-MAPT (pSer396): SAB4300081: Analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer’s Disease using Anti-phospho-MAPT (pSer396) antibody.
Immunoblotting Anti-phospho-MAPT (pSer396): SAB4300081: Analysis of extracts from mouse brain tissue using Anti-phospho-MAPT (pSer396) antibody and the same antibody preincubated with blocking peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (Y-K-SP-P-V) |
| isotype | IgG |
| mol wt | ~48 kDa |
| ~62 kDa | |
| ~78 kDa | |
| NCBI accession no. | NP_001116538.1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, human, rat |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pSer396) |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P10636 |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
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| General description: | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. |
| Immunogen: | Peptide sequence around phosphorylation site of serine 396 (Y-K-S(p)-P-V), according to the protein MAPT. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |