Anti-phospho-CDK2 (pThr160) antibody produced in rabbit
SIGMA/SAB4300110 - affinity isolated antibody
Synonym: Anti-
MDL Number: MFCD00675227
Product Type: Chemical
Immunohistochemistry Anti-phospho-CDK2 (pThr160): SAB4300110: Analysis of paraffin-embedded human breast carcinoma tissue using Anti-phospho-CDK2 (pThr160) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunoblotting Anti-phospho-CDK2 (pThr160): SAB4300110: Analysis of extracts from HeLa cells untreated (Lane 1) or treated with UV (Lane 2) using Anti-phospho-CDK2 (pThr160) antibody.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (T-Y-TP-H-E) |
| isotype | IgG |
| mol wt | ~34 kDa |
| NCBI accession no. | NP_001789.2   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, human, mouse |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pThr160) |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P24941 |
| Biochem/physiol Actions: | Cyclin-dependent kinase 2 (CDK2) protein participates in the recombination and differentiation of the cell. It plays a major role in metabolism, apoptosis, senescence, and meiosis. CDK2 is involved in the development of embryos and the remodeling of chromatin. It also plays a key role in DNA damage and DNA damage response (DDR). CDK2 controls the progression of the cell cycle. Changes in the activity of CDK2 might have an impact on human carcinogenesis. Absence of CDK2 results in DNA damage and DDR activation. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Cyclin-dependent kinase 2 (CDK2), a nucleus-cytoplasm trafficking protein, belongs to the cyclin-dependent kinase (CDK) family. The CDK2 gene is located on human chromosome 12q13.2. |
| General description: | Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2. |
| Immunogen: | Peptide sequence around phosphorylation site of threonine 160 (T-Y-T(p)-H-E), according to the protein CDK2. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |