Anti-phospho-TYK2 (pTyr1054) antibody produced in rabbit
SIGMA/SAB4300122 - affinity isolated antibody
Synonym: Anti-JTK1 antibody produced in rabbit; Anti-tyrosine kinase 2 antibody produced in rabbit
Product Type: Chemical
Immunoblotting Anti-phospho-TYK2 (pTyr1054): SAB4300122: Analysis of extracts from HT29 cells untreated (Lane 1) or treated with Anisomycin (Lane 2) using Anti-phospho-TYK2 (pTyr1054) antibody.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (H-E-YP-Y-R) |
| isotype | IgG |
| mol wt | ~140 kDa |
| NCBI accession no. | NP_003322.3   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, rat, mouse |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr1054) |
| technique(s) | western blot: 1:500-1:1000 |
| UniProt accession no. | P29597 |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
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| General description: | TYK2 encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. |
| Immunogen: | Peptide sequence around phosphorylation site of tyrosine 1054 (H-E-Y(p)-Y-R), according to the protein TYK2. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |