Anti-phospho-JAK2 (pTyr1007) antibody produced in rabbit
SIGMA/SAB4300124 - affinity isolated antibody
Synonym: Anti-JTK10 antibody produced in rabbit; Anti-Janus kinase 2 (a protein tyrosine kinase) antibody produced in rabbit
Product Type: Chemical
Immunohistochemistry Anti-phospho-JAK2 (pTyr1007): SAB4300124: Analysis of paraffin-embedded human breast carcinoma tissue using Anti-phospho-JAK2 (pTyr1007) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunoblotting Anti-phospho-JAK2 (pTyr1007): SAB4300124: Analysis of extracts from HT29 cells untreated or treated with IL-4 using Anti-phospho-JAK2 (pTyr1007) antibody.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (K-E-YP-Y-K) |
| isotype | IgG |
| mol wt | ~125 kDa |
| NCBI accession no. | NP_004963.1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, rat, human |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr1007) |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | O60674 |
| Biochem/physiol Actions: | Janus kinase 2(JAK2) plays an important role in the activities of cytokines receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy. In addition, mutations in the gene has also been observed in polycythaemia vera patients. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Janus kinase 2(JAK2) mapped on human chromosome 9p24, encodes a tyrosine kinase. The encoded protein is a member of the Jak family of protein. JAK2 is ubiquitously expressed. This protein contains a catalytic domain and protein–protein interaction domain. |
| General description: | Plays a role in leptin signaling and control of body weight. |
| Immunogen: | Peptide sequence around phosphorylation site of tyrosine 1007 (K-E-Y(p)-Y-K), according to the protein JAK2. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |