Anti-phospho-PAK1/PAK2/PAK3 (pThr423/pThr402/pThr421) antibody produced in rabbit
SIGMA/SAB4300135 - affinity isolated antibody
Synonym: Anti-ADE2 antibody produced in rabbit; Anti-CDKN1A antibody produced in rabbit; Anti-PAK65 antibody produced in rabbit
MDL Number: MFCD02097133
Product Type: Chemical
Immunohistochemistry Anti-phospho-PAICS/PAK2/PAK3 (pThr423/pThr402/pThr421): SAB4300135: Analysis of paraffin-embedded human breast carcinoma tissue using Anti-phospho-PAICS/PAK2/PAK3 (pThr423/pThr402/pThr421) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunofluorescence Anti-phospho-PAICS/PAK2/PAK3 (pThr423/pThr402/pThr421): SAB4300135: Staining of methanol-fixed HeLa cells using Anti-phospho-PAICS/PAK2/PAK3 (pThr423/pThr402/pThr421) antibody (Red).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (R-S-TP-M-V) |
| isotype | IgG |
| mol wt | 61-67 kDa |
| 68-74 kDa | |
| NCBI accession no. | NP_001121638.1   |
| NP_001122092.1 |
|
| NP_002568.2 |
|
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, human, rat |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pThr423/pThr402/pThr421) |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 |
| indirect immunofluorescence: 1:100-1:200 | |
| UniProt accession no. | Q13177 |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
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| General description: | The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. |
| Immunogen: | Peptide sequence around phosphorylation site of threonine 423 /402/421 (R-S-T(p)-M-V), according to the protein PAK1/PAK2/PAK3. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |