Anti-phospho-PRKDC (pThr2609) antibody produced in rabbit
SIGMA/SAB4300137 - affinity isolated antibody
Synonym: Anti-DNA-PKcs antibody produced in rabbit; Anti-DNAPK antibody produced in rabbit; Anti-DNPK1 antibody produced in rabbit; Anti-HYRC antibody produced in rabbit; Anti-protein kinase, DNA-activated, catalytic polypeptide antibody produced in rabbit
MDL Number: MFCD01321942
Product Type: Chemical
Immunoblotting Anti-phospho-PRKDC (pThr2609): SAB4300137: Analysis of extracts from K562 cells untreated (Lane 1) or treated with hydroxyurea (Lane 2) using Anti-phospho-PRKDC (pThr2609) antibody.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (V-E-TP-Q-A) |
| isotype | IgG |
| mol wt | ~450 kDa |
| NCBI accession no. | NP_001075109.1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pThr2609) |
| technique(s) | western blot: 1:500-1:1000 |
| UniProt accession no. | P78527 |
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| General description: | The PRKDC gene encodes the catalytic subunit of a nuclear DNA-dependent serine/threonine protein kinase (DNA-PK). The second component is the autoimmune antigen Ku (MIM 152690), which is encoded by the G22P1 gene on chromosome 22q. On its own, the catalytic subunit of DNA-PK is inactive and relies on the G22P1 component to direct it to the DNA and trigger its kinase activity; PRKDC must be bound to DNA to express its catalytic properties. |
| Immunogen: | Peptide sequence around phosphorylation site of threonine 2609 (V-E-T(p)-Q-A), according to the protein PRKDC. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |