Anti-phospho-NTRK2 (pTyr515) antibody produced in rabbit
SIGMA/SAB4300255 - affinity isolated antibody
Synonym: Anti-GP145-TrkB antibody produced in rabbit; Anti-TRKB antibody produced in rabbit; Anti-neurotrophic tyrosine kinase, receptor, type 2 antibody produced in rabbit
MDL Number: MFCD01092509
Product Type: Chemical
Immunofluorescence Anti-phospho-NTRK2 (pTyr515): SAB4300255: Staining of methanol-fixed HeLa cells using Anti-phospho-NTRK2 (pTyr515) antibody (Red).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (P-Q-Y-PF-G) |
| isotype | IgG |
| mol wt | ~140 kDa |
| NCBI accession no. | NP_001007098.1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, rat, human |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr515) |
| technique(s) | indirect immunofluorescence: 1:100-1:200 |
| UniProt accession no. | Q16620 |
| Application: | Anti-phospho-NTRK2 (pTyr515) antibody has been used in western blotting. |
| Biochem/physiol Actions: | In NB (neuroblastoma), NTRK2 (neurotrophic tyrosine kinase receptor type 2) controls the favorable and unfavorable clinical actions. It also controls the roles of glutamate receptor and synaptic plasticity in the amygdala . |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | NTRK2 (neurotrophic tyrosine kinase receptor type 2) is also known as TRKB (tropomyosin receptor kinase B). It belongs to the Trk family of neurotrophin receptors. It is located on chromosome 9q21.32. |
| General description: | Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1. |
| Immunogen: | Peptide sequence around phosphorylation site of tyrosine 515 (P-Q-Y(p)-F-G), according to the protein NTRK2. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |