Anti-phospho-ABL1/ABL2 (pTyr393/429) antibody produced in rabbit
SIGMA/SAB4300273 - affinity isolated antibody
Synonym: Anti-ABL antibody produced in rabbit; Anti-ABLL antibody produced in rabbit; Anti-ARG antibody produced in rabbit; Anti-JTK7 antibody produced in rabbit; Anti-c-abl oncogene 1 / v-abl murine leukemia viral oncogene homolog 2 antibody produced in rabbit
Product Type: Chemical
Immunohistochemistry Anti-phospho-ABL1/ABL2 (pTyr393/429): SAB4300273: Analysis of paraffin-embedded human breast carcinoma tissue using Anti-phospho-ABL1/ABL2 (pTyr393/429) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunofluorescence Anti-phospho-ABL1/ABL2 (pTyr393/429): SAB4300273: Staining of methanol-fixed HeLa cells using Anti-phospho-ABL1/ABL2 (pTyr393/429) antibody (Red).
Immunoblotting Anti-phospho-ABL1/ABL2 (pTyr393/429): SAB4300273: Analysis of extracts from HL60 cells using Anti-phospho-ABL1/ABL2 (pTyr393/429) antibody and the same antibody preincubated with blocking peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (D-T-YP-T-A) |
| isotype | IgG |
| mol wt | ~210 kDa |
| NCBI accession no. | NP_001129472.1   |
| NP_005148.2 |
|
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, mouse |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr393/pSer429) |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 |
| indirect immunofluorescence: 1:100-1:200 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P42684 |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. |
| Immunogen: | Peptide sequence around phosphorylation site of tyrosine 393/429 (D-T-Y(p)-T-A), according to the protein ABL1/ABL2. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |