Anti-STAT6 (Ab-641) antibody produced in rabbit
SIGMA/SAB4300331 - affinity isolated antibody
Synonym: Anti-D12S1644 antibody produced in rabbit; Anti-IL-4-STAT antibody produced in rabbit; Anti-STAT6B antibody produced in rabbit; Anti-STAT6C antibody produced in rabbit; Anti-signal transducer and activator of transcription 6, interleukin-4 induced antibody produced in rabbit
Product Type: Chemical
Immunohistochemistry Anti-STAT6 (Ab-641): SAB4300331: Analysis of paraffin-embedded human breast carcinoma tissue using Anti-STAT6 (Ab-641) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunoblotting Anti-STAT6 (Ab-641): SAB4300331: Analysis of extracts from HepG2 cells using Anti-STAT6 (Ab-641) antibody.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (R-G-Y-V-P) |
| isotype | IgG |
| mol wt | ~110 kDa |
| NCBI accession no. | NP_003144.3   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P42226 |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. By screening an embryonic lung fibroblast cDNA library with a wildtype STAT6 probe, 2 variant cDNAs were identified, which were termed STAT6B and STAT6C, encoding an N-terminal 110-amino acid truncation and a 27-amino acid deletion in the SH2 domain, respectively. All the three variants are ubiquitously expressed with STAT6B expression greatest in spleen and STAT6C expression greatest in lung. STAT6B resembles an attenuated STAT6, but that STAT6C inhibits IL-4-mediated mitogenesis and cell surface antigen expression, and is not tyrosine phosphorylated. |
| Immunogen: | Peptide sequence around aa. 639-643 (R-G-Y-V-P), according to the protein STAT6. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |