Anti-CAV1 (Ab-14) antibody produced in rabbit
SIGMA/SAB4300389 - affinity isolated antibody
Synonym: Anti-BSCL3 antibody produced in rabbit; Anti-CAV antibody produced in rabbit; Anti-CGL3 antibody produced in rabbit; Anti-MSTP085 antibody produced in rabbit; Anti-caveolin 1, caveolae protein, 22kDa antibody produced in rabbit
Product Type: Chemical
Immunoblotting Anti-CAV1 (Ab-14): SAB4300389: Analysis of extracts from HT29 and HUVEC cells using Anti-CAV1 (Ab-14) antibody.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (H-L-Y-T-V) |
| isotype | IgG |
| mol wt | ~24 kDa |
| NCBI accession no. | NP_001166366.1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, rat, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:500-1:1000 |
| UniProt accession no. | Q03135 |
| Biochem/physiol Actions: | Caveolin-1 is expected to play a major role in the growth and evolution of cancer. It participates in glucose metabolism. It may also participate in angiogenesis. Cav-1 helps to control the expression of glucose transporters. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
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| General description: | Caveolin-1 (CAV1) is a multifunctional scaffolding protein , that has three exons. It is located on human chromosome 7q31. |
| General description: | The scaffolding protein encoded by Caveolin-1 is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. |
| Immunogen: | Peptide sequence around aa. 12-16 (H-L-Y-T-V), according to the protein CAV1. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |