Anti-FOXO1 (Ab-256) antibody produced in rabbit
SIGMA/SAB4300410 - affinity isolated antibody
Synonym: Anti-FKH1 antibody produced in rabbit; Anti-FKHR antibody produced in rabbit; Anti-FOXO1A antibody produced in rabbit; Anti-forkhead box O1 antibody produced in rabbit
Product Type: Chemical
Immunohistochemistry Anti-FOXO1 (Ab-256): SAB4300410: Analysis of paraffin-embedded human breast carcinoma tissue using Anti-FOXO1 (Ab-256) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunofluorescence Anti-FOXO1 (Ab-256): SAB4300410: Staining of methanol-fixed HeLa cells using Anti-FOXO1 (Ab-256) antibody (Red).
Immunoblotting Anti-FOXO1 (Ab-256): SAB4300410: Analysis of extracts from HeLa cells using Anti-FOXO1 (Ab-256) antibody.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (A-A-S-M-D) |
| isotype | IgG |
| mol wt | 78-82 kDa |
| NCBI accession no. | NP_002006.2   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, human, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 |
| indirect immunofluorescence: 1:100-1:200 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | Q12778 |
| Application: | Anti-FOXO1 (Ab-256) antibody has been used in immunohistochemistry, immunofluorescence and western blotting . |
| Biochem/physiol Actions: | FOXO1 (forkhead box O1) blocks the differentiation of cell in fetal pancreatic progenitor cells. It controls the differentiation of adipocyte. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | FKHR belongs to the forkhead family of transcription factors, which are characterized by a distinct forkhead domain. It may play a role in myogenic growth and differentiation. The mammalian DAF-16-like transcription factors, FKHR, FKHRL1, and AFX, function as key regulators of insulin signaling, cell cycle progression, and apoptosis downstream of phosphoinositide 3-kinase. Gene activation through binding to insulin response sequences has been essential for mediating these functions. D-type Cyclins (in Class III) is required for FKHR mediated inhibition of cell cycle progression and transformation. FKHR gene is mapped to chromosome 13q14 |
| General description: | FOXO1 (forkhead box O1) is a transcription factor , that belongs to the Foxo subfamily. It is located on human chromosome 13q14. |
| Immunogen: | Peptide sequence around aa. 254-258 (A-A-S-M-D), according to the protein FOXO1. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |