Anti-PAK1/PAK2/PAK3 (Ab-423/402/421) antibody produced in rabbit
SIGMA/SAB4300434 - affinity isolated antibody
Synonym: Anti-CDKN1A antibody produced in rabbit; Anti-MGC130000 antibody produced in rabbit; Anti-PAK65 antibody produced in rabbit; Anti-p21 protein (Cdc42 / Rac)-activated kinase 1 / 2 / 3 antibody produced in rabbit
MDL Number: MFCD02097133
Product Type: Chemical
Immunohistochemistry Anti-PAK1/PAK2/PAK3 (Ab-423/402/421): SAB4300434: Analysis of paraffin-embedded human breast carcinoma tissue using Anti-PAK1/PAK2/PAK3 (Ab-423/402/421) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunofluorescence Anti-PAK1/PAK2/PAK3 (Ab-423/402/421): SAB4300434: Staining of methanol-fixed HeLa cells using Anti-PAK1/PAK2/PAK3 (Ab-423/402/421) antibody (Red).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (R-S-T-M-V) |
| isotype | IgG |
| mol wt | 61-67 kDa |
| 68-74 kDa | |
| NCBI accession no. | NP_001121638.1   |
| NP_001122092.1 |
|
| NP_002568.2 |
|
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 |
| indirect immunofluorescence: 1:100-1:200 | |
| UniProt accession no. | Q13177 |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. |
| Immunogen: | Peptide sequence around aa. 421-425/400-404/419-423 (R-S-T-M-V), according to the proteins PAK1/PAK2/PAK3. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |