Anti-RPS6KA5 (Ab-376) antibody produced in rabbit
SIGMA/SAB4300458 - affinity isolated antibody
Synonym: Anti-MGC1911 antibody produced in rabbit; Anti-MSK1 antibody produced in rabbit; Anti-MSPK1 antibody produced in rabbit; Anti-RLPK antibody produced in rabbit; Anti-ribosomal protein S6 kinase, 90kDa, polypeptide 5 antibody produced in rabbit
MDL Number: MFCD02686432
Product Type: Chemical
Immunoblotting Anti-RPS6KA5 (Ab-376): SAB4300458: Analysis of extracts from HUVEC cells using Anti-RPS6KA5 (Ab-376) antibody and the same antibody preincubated with blocking peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (G-Y-S-F-V) |
| isotype | IgG |
| mol wt | ~90 kDa |
| NCBI accession no. | NP_004746.2   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:500-1:1000 |
| UniProt accession no. | O75582 |
| Biochem/physiol Actions: | RPS6KA5 (ribosomal protein S6 kinase A5)/mitogen- and stress-activated kinase 1 (MSK1) acts as a connector between extracellular signals and gene expression. It helps in the phosphorylation of chromatin protein histone H3 and high mobility group 14 (HMG14) . MSK1 plays a key role in the development of hormone-dependent breast cancer. |
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| General description: | RPS6KA5 (ribosomal protein S6 kinase A5)/mitogen- and stress-activated kinase 1 (MSK1) is a nuclear serine/threonine protein kinase , that is located on human chromosome 14q32. It is a dual kinase domain protein. |
| General description: | Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14). |
| Immunogen: | Peptide sequence around aa. 374-378 (G-Y-S-F-V), according to the protein RPS6KA5. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |