Anti-PTK2B (Ab-402) antibody produced in rabbit
SIGMA/SAB4300468 - affinity isolated antibody
Synonym: Anti-CADTK antibody produced in rabbit; Anti-CAKB antibody produced in rabbit; Anti-FADK2 antibody produced in rabbit; Anti-FAK2 antibody produced in rabbit; Anti-PTK2B protein tyrosine kinase 2 beta antibody produced in rabbit
MDL Number: MFCD01634069
Product Type: Chemical
Immunohistochemistry Anti-PTK2B (Ab-402): SAB4300468: Analysis of paraffin-embedded human breast carcinoma tissue using Anti-PTK2B (Ab-402) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunofluorescence Anti-PTK2B (Ab-402): SAB4300468: Staining of methanol-fixed HeLa cells using Anti-PTK2B (Ab-402) antibody (Red).
Immunoblotting Anti-PTK2B (Ab-402): SAB4300468: Analysis of extracts from Jurkat cells using Anti-PTK2B (Ab-402) antibody and the same antibody preincubated with blocking peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (D-I-Y-A-E) |
| isotype | IgG |
| mol wt | ~116 kDa |
| NCBI accession no. | NP_004094.3   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 |
| indirect immunofluorescence: 1:100-1:200 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | Q14289 |
| Application: | Anti-PTK2B (Ab-402) antibody has been used in immunohistofluorescence. |
| Biochem/physiol Actions: | Protein tyrosine kinase 2 |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation. |
| General description: | PTK2B/ Pyk2 (proline-rich tyrosine kinase 2β) is a non receptor protein kinase that belongs to the focal adhesion kinase family. It is also known as FAK2 (focal adhesion kinase 2), RAFTK (related adhesion focal tyrosine kinase) and CAKB (cell adhesion kinase beta). Its expression is confined to the endothelium, central nervous system and hematopoietic lineages. It is located on human chromosome 8p21.1. |
| Immunogen: | Peptide sequence around aa. 400-404 (D-I-Y-A-E), according to the protein PTK2B. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |