Anti-GAP43 (Ab-41) antibody produced in rabbit
SIGMA/SAB4300525 - affinity isolated antibody
Synonym: Anti-B-50 antibody produced in rabbit; Anti-PP46 antibody produced in rabbit; Anti-growth associated protein 43 antibody produced in rabbit
MDL Number: MFCD00164594
Product Type: Chemical
Immunohistochemistry Anti-GAP43 (Ab-41): SAB4300525: Analysis of paraffin-embedded human breast carcinoma tissue using Anti-GAP43 (Ab-41) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunofluorescence Anti-GAP43 (Ab-41): SAB4300525: Staining of methanol-fixed HeLa cells using Anti-GAP43 (Ab-41) antibody (Red).
Immunoblotting Anti-GAP43 (Ab-41): SAB4300525: Analysis of extracts from mouse brain tissue using Anti-GAP43 (Ab-41) antibody and the same antibody preincubated with blocking peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (Q-A-S-F-R) |
| isotype | IgG |
| mol wt | ~43 kDa |
| NCBI accession no. | NP_001123536.1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 |
| indirect immunofluorescence: 1:100-1:200 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P17677 |
| Biochem/physiol Actions: | Growth associated protein-43 (GAP-43) participates in neurite outgrowth, growth cone navigation, neurotransmission, stabilization of axonal branches and synaptic plasticity. In humans and mice, GAP43 is recognized as a possible gene for autism and autistic-like disorders. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | GAP43 encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
| General description: | Growth associated protein-43 (GAP-43) is a phosphoprotein associated with membrane. It is located on chromosome 3q13. During neural development and axonal regeneration, GAP43 is upregulated in neuronal growth cones and Schwann cell precursors. |
| Immunogen: | Peptide sequence around aa. 38-43 (Q-A-S-F-R), according to the protein GAP43. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |