Anti-HSP90AB1 (Ab-254) antibody produced in rabbit
SIGMA/SAB4300541 - affinity isolated antibody
Synonym: Anti-D6S182 antibody produced in rabbit; Anti-FLJ26984 antibody produced in rabbit; Anti-HSP90-BETA antibody produced in rabbit; Anti-HSP90B antibody produced in rabbit; Anti-heat shock protein 90kDa alpha (cytosolic), class B member 1 antibody produced in rabbit
MDL Number: MFCD07370344
Product Type: Chemical
Immunohistochemistry Anti-HSP90AB1 (Ab-254): SAB4300541: Analysis of paraffin-embedded human breast carcinoma tissue using Anti-HSP90AB1 (Ab-254) antibody (left) or the same antibody preincubated with blocking peptide (right).
Immunofluorescence Anti-HSP90AB1 (Ab-254): SAB4300541: Staining of methanol-fixed HeLa cells showing cytoplasmic staining using Anti-HSP90AB1 (Ab-254) antibody.
Immunoblotting Anti-HSP90AB1 (Ab-254): SAB4300541: Analysis of extracts from HeLa and A2780 cells using Anti-HSP90AB1 (Ab-254) antibody.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (V-G-S-D-E) |
| isotype | IgG |
| mol wt | ~92 kDa |
| NCBI accession no. | NP_031381.2   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, rat, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 |
| indirect immunofluorescence: 1:100-1:200 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P08238 |
| Biochem/physiol Actions: | HSP90AB1 (heat shock protein 90 αfamily class B member 1) participates in signal transduction, protein folding and degradation, and morphological evolution. It is required for the transport of client proteins between the cytoplasm and nucleus. In lung adenocarcinoma patients, overexpression of HSP90AB1 in non-small cell lung cancer tissues results in imperfect clinical predictions. Suppression of this gene reduces the potential of endothelial cells to form tube structures. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | HSP90AB1 (heat shock protein 90 αfamily class B member 1) belongs to the Hsp90 family. It consists of major members-Hsp90α, Hsp90β, GRP94 (glucose-regulated protein 94) and Hsp75. It is located on chromosome 6p21. It is an ATP-dependent molecular chaperone, that is of 90kDa. |
| General description: | Molecular chaperone. Has ATPase activity. |
| Immunogen: | Peptide sequence around aa. 252-256 (V-G-S-D-E), according to the protein HSP90AB1. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |