Anti-ATR (Ab-428) antibody produced in rabbit
SIGMA/SAB4300576 - affinity isolated antibody
Synonym: Anti-FRP1 antibody produced in rabbit; Anti-MEC1 antibody produced in rabbit; Anti-SCKL antibody produced in rabbit; Anti-SCKL1 antibody produced in rabbit; Anti-ataxia telangiectasia and Rad3 related antibody produced in rabbit
Product Type: Chemical
Immunohistochemistry Anti-ATR (Ab-428): SAB4300576: Analysis of paraffin-embedded human breast carcinoma tissue using Anti-ATR (Ab-428) antibody (left) or the same antibody preincubated with blocking peptide (right).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (G-I-S-P-K) |
| isotype | IgG |
| mol wt | ~250 kDa |
| NCBI accession no. | NP_001175.2   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 |
| UniProt accession no. | Q13535 |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | ATR encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. |
| Immunogen: | Peptide sequence around aa. 426-430 (G-I-S-P-K), according to the protein ATR. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |