Anti-JAK2 (Ab-570) antibody produced in rabbit
SIGMA/SAB4300587 - affinity isolated antibody
Synonym: Anti-JTK10 antibody produced in rabbit; Anti-Janus kinase 2 (a protein tyrosine kinase) antibody produced in rabbit
Product Type: Chemical
Immunohistochemistry Anti-JAK2 (Ab-570): SAB4300587: Analysis of paraffin-embedded human breast carcinoma tissue using Anti-JAK2 (Ab-570) antibody (left) or the same antibody preincubated with blocking peptide (right).
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (G-D-Y-G-Q) |
| isotype | IgG |
| mol wt | ~125 kDa |
| NCBI accession no. | NP_004963.1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 |
| UniProt accession no. | O60674 |
| Biochem/physiol Actions: | JAK2 (janus kinase 2) plays an important role in the activities of cytokines receptors. Overexpression of JAK2 results in neuroblastoma. JAK2 mutations promote primary resistance to PD-1 (anti-programmed death protein 1) blockade therapy. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | JAK2 (janus kinase 2) encodes a tyrosine kinase. It belongs to the the Jak family of protein. It is located on chromosome 9p24. |
| General description: | Plays a role in leptin signaling and control of body weight. |
| Immunogen: | Peptide sequence around aa. 568-572 (G-D-Y-G-Q), according to the protein JAK2. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |