Anti-Cry1 antibody produced in rabbit
SIGMA/SAB4300613 - affinity isolated antibody
Synonym: Anti-AU020726 antibody produced in rabbit; Anti-AU021000 antibody produced in rabbit; Anti-Phll1 antibody produced in rabbit; Anti-cryptochrome 1 (photolyase-like) antibody produced in rabbit
Product Type: Chemical
Immunoblotting Anti-Cry1: SAB4300613: Analysis of extracts from mouse brain tissue using Anti-Cry1
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (S-Q-G-S-G) |
| isotype | IgG |
| mol wt | ~60 kDa |
| NCBI accession no. | NP_031797.1   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:500-1:1000 |
| UniProt accession no. | P97784 |
| Biochem/physiol Actions: | Cry1 (cryptochrome circadian regulator 1) controls gluconeogenesis. It induces tumor development and multiplication. Overexpression of Cry1 results in tumor progression and poor clinical indications in individuals with colorectal Cancer. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL. |
| General description: | Cry1 (cryptochrome circadian regulator 1) belongs to the cryptochrome family. It is located on human chromosome 12q23. |
| Immunogen: | Peptide sequence around aa. 551-555 (S-Q-G-S-G), according to the protein Cry1. |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |