Anti-GAPDH antibody produced in rabbit

SIGMA/SAB4300645 - affinity isolated antibody

Synonym: Anti-G3PD; Anti-GAPD; Anti-MGC88685

Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SAB4300645-100UG	100 µg	$565.00 1/EA		Add To Favorites

Immunoblotting Anti-GAPDH Cat. No. SAB4300645: Analysis of extract from JK, HL-60, HUVEC and HeLa cells using Anti-GAPDH antibody.

Properties
Descriptions
Safety Info.
Basic Data

antibody form	affinity isolated antibody
antibody product type	primary antibodies
biological source	rabbit
clone	polyclonal
concentration	1 mg/mL
conjugate	unconjugated
form	buffered aqueous solution
immunogen sequence	(P-A-K-Y-D)
isotype	IgG
mol wt	~37 kDa
NCBI accession no.	NM_002046.3
Quality Level	100
shipped in	wet ice
species reactivity	human, rat, mouse
storage temp.	−20°C
target post-translational modification	unmodified
technique(s)	western blot: 1:500-1:1000
UniProt accession no.	P04406

Application:	Anti-GAPDH antibody has been used in western blotting.{60,61}
Biochem/physiol Actions:	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays an important role in DNA repair. It is essential for the sixth step of glycolysis. It participates in transcriptional and posttranscriptional gene regulation. It also controls intracellular membrane trafficking and cell death. Accumulation of GAPDH results in mitochondrial dysfunction.
Disclaimer:	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits:	Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description:	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional protein , that is located on chromosome 12p13. It is basically called as a glycolytic enzyme. The antibody detects endogenous level of total GAPDH protein.
General description:	Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC By similarity. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate.
Immunogen:	Peptide sequence around aa. 252-256 (P-A-K-Y-D), according to the protein NP_002037.2
Physical form:	Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

RIDADR	NONH for all modes of transport
WGK Germany	WGK 1
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	12352203

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