Anti-hnRNP A1 (Ab-192) antibody produced in rabbit
SIGMA/SAB4300651 - affinity isolated antibody
Synonym: Anti-HNRPA1; Anti-HNRPA1L3; Anti-MGC102835; Anti-hnRNP A1; Anti-hnRNP-A1
Product Type: Chemical
Immunoblotting Anti-hnRNP A1 (Ab-192) Cat. No. SAB4300651: Analysis of extract from 293 cells using Anti-hnRNP A1 (Ab-192) antibody.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (S-S-S-Q-R) |
| isotype | IgG |
| mol wt | 34-39 kDa |
| NCBI accession no. | NM_002136.2   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | mouse, rat, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:500-1:1000 |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a member of the hnRNP A/B family of related RNA binding proteins that bind pre-mRNA and are involved in the processing, metabolism and transport of nuclear pre-mRNA transcripts . hnRNP A1 regulates the alternative splicing of c-Src, c-H-Ras and modifies initiation of translation of the fibroblast growth factor 2 mRNA. hnRNP A1 expression level is elevated in many cancers; knockdown of hnRNP A1 leads to apoptosis in various cancer cells . Although predominantly nuclear, hnRNP A1 is continually transported from the nucleus to the cytoplasm where it disassociates from mRNA and is rapidly re-imported into the nucleus . hnRNP A1 binds to cis-acting repressive sequences (CRS) of HIV-1 to influence HIV-1 production . HIV-1 enhances hnRNP A1 expression and promotes the relocalization of hnRNP A1 to the cytoplasm , |
| General description: | The antibody detects endogenous levels of total hnRNP A1 protein. |
| Immunogen: | Peptide sequence around aa. 190-194 (S-S-S-Q-R), according to the protein NP_002127.1 |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |