Anti-Ring1A antibody produced in rabbit
SIGMA/SAB4300706 - affinity isolated antibody
Synonym: Anti-RING1; Anti-RNF1
Product Type: Chemical
Immunoblotting Anti-Ring1A Cat. No. SAB4300706: Analysis of extract from HeLa cells using Anti-Ring1A antibody.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| immunogen sequence | (I-A-V-S-P) |
| isotype | IgG |
| mol wt | ~58 kDa |
| NCBI accession no. | NM_002931.3   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:500-1:1000 |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of ′Lys-119′ of histone H2A, thereby playing a central role in histone code and gene regulation. H2A ′Lys-119′ ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. |
| General description: | The antibody detects endogenous level of total Ring1A protein. |
| Immunogen: | Peptide sequence around aa. 35-39 ( I-A-V-S-P), according to the protein NP_002922.2 |
| Physical form: | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |