Anti-SLCO1B1 antibody produced in rabbit
SIGMA/SAB4300781 - affinity isolated antibody
Synonym: LST-1; Liver-specific organic anion transporter 1; OATP 2; Sodium-independent organic anion-transporting polypeptide 2; Solute carrier family 21 member 6
Product Type: Product-on-demand
Immunoblotting Anti-SLCO1B1: Cat. No. SAB4300781: Western blot analysis of extracts from COLO205 and Jurkat cells using Anti-SLCO1B1 antibody. The lane on the right is treated with the synthesized peptide.
| accession no. | NP_006437.3 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1.0 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| isotype | IgG |
| mol wt | 76 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:500-1:3000 (Cell Lysate) |
| UniProt accession no. | Q9Y6L6  |
| Biochem/physiol Actions: | Solute carrier organic anion transporter family member 1B1 (SLCO1B1) transports taurocholate, conjugated steroids, eicosanoids, and thyroid hormones, in a sodium independent manner. SLCO1B1 is the key transporter of bile for the clearance of human liver. Polymorphism in SLCO1B1 might lead to life threatening drug toxicities. Mutations in SLCO1B1 and SLCO1B3 leads to rotor syndrome in human, affecting conjugated bilirubin reuptake in liver. Genetic variability in SLCO1B1 affects the plasma concentration of statins. |
| Biochem/physiol Actions: | The antibody detects endogenous levels of total SLCO1B1 protein. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
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| General description: | Solute carrier organic anion transporter family member 1B1 (SLCO1B1) or liver-specific organic anion transporter 1 (LST-1) and sodium-independent organic anion-transporting polypeptide 2 (OATP-2), is formerly known as solute carrier family 21 (organic anion transporter), member 6 (SLC21A6). SLCO1B1 is predominantly expressed in liver. It is expressed in the basolateral membrane. It has 12 transmembrane domains. In human chromosome, the gene SLCO1B1 is localized on 12p12.1 |
| Immunogen: | Synthesized peptide derived from internal of human SLCO1B1. |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |