Anti-NeuN antibody produced in rabbit
SIGMA/SAB4300883 - affinity isolated antibody
Synonym: FLJ56884; FLJ58356; FOX3; HRNBP3; RBFOX3
Product Type: Product-on-demand
Immunoblotting Anti-NeuN: Cat. No. SAB4300883: Western blot analysis of extracts of various cell lines using Anti-NeuN antibody.
| accession no. | NP_001076044.1 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1.0 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| isotype | IgG |
| mol wt | 34 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:500-1:2000 (Cell Lysate) |
| UniProt accession no. | A6NFN3  |
| Application: | Anti-NeuN antibody produced in rabbit has been used in Immunohistochemical staining. |
| Biochem/physiol Actions: | NeuN (neuronal nuclei)/RBFOX3 (RNA binding protein, fox-1 homolog 3) is a RNA splicing factor. It controls neuronal splicing pathway. NeuN is used as a potential marker of postmitotic neurons in studies of neuronal differentiation and in the evaluation of neuronal status both in norm and pathology. Mutation in the gene is associated with risk of rolandic epilepsy. Studies have shown that in presence of neurological disorders, the protein is mislocalized. |
| Biochem/physiol Actions: | The antibody detects endogenous level of total NeuN protein. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | NeuN (neuronal nuclei), also known as RBFOX3 (RNA binding protein, fox-1 homolog 3), is encoded by the gene mapped to human chromosome 17q25.3. The encoded protein belongs to the RBFOX family of proteins. NeuN is present in nuclei and perinuclear cytoplasm of most of the neurons in the central nervous system (CNS) of mammals. |
| Immunogen: | Recombinant protein of human NeuN. |
| Physical form: | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |