Anti-MT-ND1 antibody produced in rabbit
SIGMA/SAB4300926 - affinity isolated antibody
Synonym: EC 1.6.5.3; MT-ND1; MTND1; NADH dehydrogenase subunit 1; NADH-ubiquinone oxidoreductase chain 1
Product Type: Product-on-demand
Immunohistochemistry Anti-MT-ND1: Cat. No. SAB4300926: Immunohistochemical analysis of paraffin-embedded Human placenta tissue using Anti-MT-ND1 antibody.
Immunoblotting Anti-MT-ND1: Cat. No. SAB4300926: Western blot analysis of extracts from A549 cells and COLO cells using Anti-MT-ND1 antibody.
| accession no. | P03886 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1.0 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| isotype | IgG |
| mol wt | 36 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: 1:50-1:100 |
| western blot: 1:500-1:3000 (Cell Lysate) | |
| UniProt accession no. | P03886  |
| Biochem/physiol Actions: | Mitochondrially encoded NADH dehydrogenase 1 (MT-ND1) participates in ubiquinone binding and proton pumping. Mutations in the MT-ND1 gene are implicated in Leber′s hereditary optic neuropathy (LHON), as well as in mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). Also, some heteroplasmic mutations in the MTND1 gene are associated with an overlap syndrome showing the clinical features associated with LHON and MELAS. |
| Biochem/physiol Actions: | The antibody detects endogenous levels of total MT-ND1 protein. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Mitochondrially encoded NADH dehydrogenase 1 (MT-ND1) is a component of mitochondrial membrane respiratory chain nicotinamide adenine dinucleotide (NADH) dehydrogenase (Complex I). It comprises eight transmembrane spanning domains and is a conserved protein placed in the hydrophobic arm of the complex I. |
| Immunogen: | Synthesized peptide derived from internal of human MT-ND1. |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |