Anti-TDP2 antibody produced in rabbit
SIGMA/SAB4301078 - affinity isolated antibody
Synonym: AD022; EAP2; EAPII; TTRAP; hTDP2
Product Type: Product-on-demand
Immunohistochemistry Anti-TDP2: Cat. No. SAB4301078: Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using Anti-TDP2 antibody.
Immunoblotting Anti-TDP2: Cat. No. SAB4301078: Western blot analysis of extracts from HeLa and 293T cells (from left to right) using Anti-TDP2 antibody.
| accession no. | NP_057698.2 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 2.6 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| isotype | IgG |
| mol wt | 41 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: 1:50- 1:200 |
| western blot: 1:200-1:1000 (Cell Lysate) | |
| UniProt accession no. | O95551  |
| Biochem/physiol Actions: | Chromosomal translocations stimulated by DNA topoisomerase II at the time of gene transcription is repressed by tyrosyl DNA phosphodiesterase-2 (TDP2). It is essential to preserve the chromosome stability in human cells. TDP2 participates in cell proliferation, apoptosis and the repair of DNA damage. It promotes cell cycle arrest and apoptosis in osteosarcoma cells. |
| Biochem/physiol Actions: | The antibody detects endogenous levels of total TDP2 protein. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Tyrosyl DNA phosphodiesterase-2 (TDP2) is a multi-functional protein and is also called as TTRAP (TNF receptor-associated protein). It is a 5′- tyrosyl DNA phosphodiesterase that belongs to the PML NB (promyelocytic leukemia nuclear body) protein family. TDP2 is mapped to human chromosome 6p22. |
| Immunogen: | Synthetic peptide corresponding to a region derived from internal residues of human tyrosyl-DNA phosphodiesterase 2 |
| Physical form: | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |