Anti-pan-AKT antibody produced in rabbit
SIGMA/SAB4301170 - affinity isolated antibody
Synonym: PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA
Product Type: Product-on-demand
Immunoblotting Anti-pan-AKT : Cat. No. SAB4301170: Western blot analysis of extracts from NIH/3T3 and HeLa cells (from left to right) using Anti-pan-AKT antibody.
| accession no. | NP_001014431.1 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 2 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| isotype | IgG |
| mol wt | 56 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | rat, human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | western blot: 1:500-1:1000 (Cell Lysate) |
| UniProt accession no. | P31749  |
| Application: | Anti-pan-AKT antibody produced in rabbit has been used in immunoblotting. |
| Biochem/physiol Actions: | AKT serine/threonine kinase 1 (AKT1) acts as a regulator for cell-survival and anti-apoptotic actions which are involved in development of various cancers. This protein has a crucial role in tumorigenesis. In mice, AKT1 is essential for normal development. Mutations in the gene are associated with the pathogenesis of prostate cancer (PC). Elevated expression of the gene has been observed in human gastric cancer. Aberrations in the AKT1 and glycogen synthase kinase 3 (GSK3)-β signaling leads to the development of schizophrenia. |
| Biochem/physiol Actions: | The antibody detects endogenous levels of total pan-AKT protein. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | AKT serine/threonine kinase 1 (AKT1) also called as v-akt murine thymoma viral oncogene homolog 1 or protein kinase B α (PKB α) is encoded by the gene mapped to human chromosome 14q32. It is highly expressed in liver, muscle and adipocytes. The encoded protein is a member of AKT family, which is characterized with an amino-terminal pleckstrin homology (PH) domain, a short α-helical linker and a carboxyl-terminal kinase domain. |
| Immunogen: | Synthetic peptide corresponding to a region derived from internal residues of human RAC-alpha serine/threonine-protein kinase |
| Physical form: | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |