Anti-phospho-BLK (pTyr501) antibody produced in rabbit
SIGMA/SAB4301289 - affinity isolated antibody
Synonym: B lymphocyte kinase; EC 2.7.10.2; Tyrosine-protein kinase BLK; kinase Blk; p55-BLK
Product Type: Product-on-demand
Immunohistochemistry Anti-phospho-BLK (pTyr501): Cat. No. SAB4301289: Immunohistochemical analysis of paraffin-embedded Human breast carcinoma tissue using Anti-phospho-BLK (pTyr501) antibody
| accession no. | NP_001706.2. |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | 1.0 mg/mL |
| form | buffered aqueous solution |
| isotype | IgG |
| mol wt | 57 kDa |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | phosphorylation (pTyr501) |
| technique(s) | immunohistochemistry: 1:50-1:100 |
| UniProt accession no. | P51451  |
| Biochem/physiol Actions: | B lymphoid tyrosine kinase (BLK) protein has oncogenic properties. It helps B-cell receptors transmit signals and may be important for B-cell repertoire development and mature B-cell activity. BLK participates in B-cell antigen receptor signaling. The BLK gene polymorphisms are linked to renal dysfunction in people with systemic lupus erythematosus. |
| Biochem/physiol Actions: | The antibody detects endogenous levels of BLK only when phosphorylated at tyrosine 501. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | B lymphoid tyrosine kinase (BLK) protein belongs to the Src kinase family. It has an Src homology 3 (SH3) and an Src homology 2 (SH2) domain N-terminal to the catalytic kinase domain. The BLK gene is located on human chromosome 8p23.1. |
| Immunogen: | Peptide sequence around phosphorylation site of tyrosine 501 (R-Q-Y(p)-E-L) derived from Human BLK. |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |