Anti-CSPG4
SIGMA/SAB4301658 - affinity isolated antibody
Synonym: HMW-MAA; MCSP; MCSPG; MSK16; NG2
Product Type: Product-on-demand
Immunohistochemistry Anti-CSPG4: Cat. No. SAB4301658: Immunohistochemical analysis of paraffin-embedded Human Brain tissue at dilution 1/25.
Immunoblotting Anti-CSPG4: Cat. No. SAB4301658: Gel: 6% SDS-PAGE Lysate: 40 μg Mouse skin tissue. Primary antibody: 1/200 dilution. Secondary antibody dilution: 1/8,000. Exposure time: 1 minute.
| accession no. | NP_001888 |
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| form | buffered aqueous glycerol solution |
| Quality Level | 100  |
| shipped in | wet ice |
| species reactivity | human, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | immunohistochemistry: 1:20-1:100 |
| western blot: 1:500-1:2000 | |
| UniProt accession no. | Q6UVK1  |
| Biochem/physiol Actions: | Chondroitin sulfate proteoglycan 4 (CSPG4) is a cell surface antigen, expressed in most human melanoma and is crucial for tumour progression and invasion. MCSP activates cell division control protein 42 homolog (Cdc42) and Cdc42-associated tyrosine kinase-1 (Ack-1) to form complex, which signals and leads to melanoma progression and metastasis. The complex of MCSP with membrane-type 3 matrix metalloproteinase (MT3-MMP) signals melanoma invasion and proteolysis. MCSP is associated with angiogenesis dependent processes like tumor growth and healing of wound. MCSP plays a key role in regulating chondrosarcoma and provides resistance to chemotherapy. CSPG4 is a prognostic marker for glioblastoma. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Chondroitin sulfate proteoglycan 4 (CSPG4) is commonly known as Melanoma chondroitin sulphate proteoglycan (MCSP). MCSP is a transmembrane protein. MCSP is lower in normal melanocytes. In human chromosome, the gene CSPG4 is localized on 15q24.2. |
| Immunogen: | Synthetic peptide corresponding to residues near the C terminal of human chondroitin sulfate proteoglycan 4 |
| Physical form: | Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |