Anti-TRXR2 antibody produced in rabbit
SIGMA/SAB4500131 - affinity isolated antibody
Synonym: Selenoprotein Z; TR-β; Thioredoxin reductase 2; Thioredoxin reductase TR3
Product Type: Chemical
Immunohistochemistry Anti-TRXR2: Cat. No. SAB4500131: Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Anti-TRXR2 antibody. Cells on the left were treated with the Anti-TRXR2 antibody. Cells on the right (negative control) were treated with both Anti-TRXR2 antibody and the synthesized immunogen peptide.
Western Blotting Anti-TRXR2: Cat. No. SAB4500131: Immunoblotting analysis of extracts from HT29 cells, using Anti-TRXR2 antibody. The lane on the left was treated with the Anti-TRXR2 antibody. The lane on the right (negative control) was treated with both Anti-TRXR2 antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 56 kDa |
| NCBI accession no. | Q9NNW7   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:10000 |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | Q9NNW7 |
| Biochem/physiol Actions: | Thioredoxin reductase 2 (TRXR2) regulates cell survival during mammalian embryonic development. In addition, it also regulates mitochondria-dependent apoptosis. TRXR2 also controls protein tyrosine phosphorylation and cell proliferation. The protein expression is associated with development of glioma. In humans, this enzyme stimulates the apoptosis in HeLa cells. Mutation in the gene might increase the risk of susceptibility to myocardial infarction (MI) in type 2 diabetes mellitus (T2DM) patients. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-TRXR2 Antibody detects endogenous levels of total TRXR2 protein. |
| General description: | Thioredoxin reductase 2 (TRXR2) is mitochondrial protein-disulfide oxidoreductase, encoded by the gene mapped to human chromosome 22q11.21. TRXR2 is one of the mammalian isoforms of thioredoxin reductase (TrxR). |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human TRXR2. Immunogen Range: 471-520 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |