Anti-CBP antibody produced in rabbit
SIGMA/SAB4500455 - affinity isolated antibody
Synonym: CREB-binding protein; CREBBP
MDL Number: MFCD02262673
Product Type: Chemical
Immunohistochemistry Anti-CBP: Cat. No. SAB4500455: Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using Anti-CBP antibody. Cells on the left were treated with the Anti-CBP antibody. Cells on the right (negative control) were treated with both Anti-CBP antibody and the synthesized immunogen peptide.
Immunofluorescence Anti-CBP: Cat. No. SAB4500455: Immunofluorescence of HeLa cells using Anti-CBP antibody. Cells on the left were treated with the Anti-CBP antibody. Cells on the right (negative control) were treated with both Anti-CBP antibody and the synthesized immunogen peptide.
Western Blotting Anti-CBP: Cat. No. SAB4500455: Immunoblotting analysis of extracts from HT-29 cells, treated with calyculinA 50ng/ml 30′, using Anti-CBP antibody. The lane on the left was treated with the Anti-CBP antibody. The lane on the right (negative control) was treated with both Anti-CBP antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 265 kDa |
| NCBI accession no. | Q92793   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, rat, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:20000 |
| immunofluorescence: 1:100-1:500 | |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | Q92793 |
| Biochem/physiol Actions: | CREB binding protein (CBP) has a role in the activation of the innate immune response, activation of histones and non-histones through acetylation. It also plays an important role in cAMP-dependent and Wnt signaling. The protein is also involved in modulating the cell cycle, DNA damage repair, ubiquitination and antigen presentation. Mutations in the CBP gene have been associated with Rubinstein-Taybi syndrome. It has also been linked with acute lymphoblastic leukemia. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-CBP Antibody detects endogenous levels of total CBP protein. CREB binding protein (CBP) is a histone acetyltransferase, which is part of the KAT3 family of histone acetyltransferases. The gene encoding it is localized on human chromosome 16p13.3. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human CBP. Immunogen Range: 1501-1550 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |