Anti-p38 MAPK antibody produced in rabbit
SIGMA/SAB4500493 - affinity isolated antibody
Synonym: MAP kinase MXI2; MAP kinase p38; MAPK14; kinase p38-α
MDL Number: MFCD00803556
Product Type: Chemical
Western Blotting Anti-p38 MAPK: Cat. No. SAB4500493: Immunoblotting analysis of extracts from 293/RAW246.7 cells, using Anti-p38 MAPK antibody. The lane on the left was treated with the Anti-p38 MAPK antibody. The lane on the right (negative control) was treated with both Anti-p38 MAPK antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 41 kDa |
| NCBI accession no. | Q16539   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, rat, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:10000 |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | Q16539 |
| Application: | Anti-p38 MAPK antibody produced in rabbit has been used in western blot analysis. |
| Biochem/physiol Actions: | p38 mitogen-activated protein kinase (MAPK)/MAPK14 (mitogen-activated protein kinase 14) participates in resistance of colon cancer cells to camptothecin-related drugs. This protein is required for the growth of embryos. This gene controls proliferation, differentiation, cell death, adhesion, migration, as well as the response to stress and many metabolic pathways. Genetic variation in p38α leads to deletion or overproduction of myelosuppressive cytokines and result in certain bone marrow failure syndromes. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-p38 MAPK Antibody detects endogenous levels of total p38 MAPK protein. |
| General description: | p38 mitogen-activated protein kinase (MAPK), also known as, mitogen-activated protein kinase 14 (MAPK14)/ p38α, is encoded by the gene mapped on human chromosome 6p21.31. The encoded protein is a Ser/Thr kinase composed of 90 to 360 residues. p38α MAPK is ubiquitously expressed. It is found in the cytosol, but it can translocate to the nucleus. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human p38 MAPK. Immunogen Range: 147-196 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |