Anti-Catenin-β antibody produced in rabbit
SIGMA/SAB4500545 - affinity isolated antibody
Synonym: CATNB; CTNB1; CTNNB; catenin β; catenin (cadherin-associated protein) β 1
MDL Number: MFCD00282178
Product Type: Chemical
Western Blotting Anti-Catenin-β: Cat. No. SAB4500545: Immunoblotting analysis of extracts from 293 cells, using Anti-Catenin-β antibody. The lane on the left was treated with the Anti-Catenin-β antibody. The lane on the right (negative control) was treated with both Anti-Catenin-β antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 85 kDa |
| NCBI accession no. | P35222   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:40000 |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P35222 |
| Biochem/physiol Actions: | Mutations in β-Catenin results in retinal vascular condition FEVR (familial exudative vitreoretinopathy). It participates in stimulating disease progression, providing to BCR–ABL (fusion gene) kinase-independent resistance and LSC (leukemic stem cell) self-renewal. It plays an important role in cell-to-cell adhesion and transcriptional modulation in the Wnt signalling pathway. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-Catenin-β Antibody detects endogenous levels of total Catenin-β protein. |
| General description: | Catenin-β is a multifunctional protein, coded by CTNNB1 (catenin β 1) gene. It is present in the intracellular side of the cytoplasmic membrane. It is located on human chromosome 3p22.1. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human Catenin-beta. Immunogen Range: 455-504 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |