Anti-MKP1 antibody produced in rabbit
SIGMA/SAB4500675 - affinity isolated antibody
Synonym: 3CH134; CL100; DUS1; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1
Product Type: Chemical
Immunohistochemistry Anti-MKP1: Cat. No. SAB4500675: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-MKP1 antibody. Cells on the left were treated with the Anti-MKP1 antibody. Cells on the right (negative control) were treated with both Anti-MKP1 antibody and the synthesized immunogen peptide.
Western Blotting Anti-MKP1: Cat. No. SAB4500675: Immunoblotting analysis of extracts from Jurkat cells, using Anti-MKP1 antibody. The lane on the left was treated with the Anti-MKP1 antibody. The lane on the right (negative control) was treated with both Anti-MKP1 antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 39 kDa |
| NCBI accession no. | P28562   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:5000 |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 |
| Biochem/physiol Actions: | In mast cells, MKP1 (mitogen-activated protein kinase phosphatase 1) blocks the functions of extracellular signal-regulated kinase (Erk)‐1/2 by glucocorticoid. It controls axon branching promoted by BDNF (brain-derived neurotrophic factor). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-MKP1 Antibody detects endogenous levels of total MKP1 protein. |
| General description: | MKP1 (mitogen-activated protein kinase phosphatase 1)/DUSP1 (dual specificity phosphatase 1) is a dual specificity phosphatase. It is also called as CL100, 3CH134 and Erp. MKP1 is located in the nucleus and is expressed in several tissues. It is located on human chromosome 5q35. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human MKP1. Immunogen Range: 318-367 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |