Anti-GLP1R antibody produced in rabbit
SIGMA/SAB4501220 - affinity isolated antibody
Synonym: GLP-1 receptor; GLP-1-R; GLP-1R; GLP1R; Glucagon-like peptide 1 receptor
Product Type: Chemical
Immunofluorescence Anti-GLP1R: Cat. No. SAB4501220: Immunofluorescence of HeLa cells using Anti-GLP1R antibody. Cells on the left were treated with the Anti-GLP1R antibody. Cells on the right (negative control) were treated with both Anti-GLP1R antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 53 kDa |
| NCBI accession no. | P43220   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:5000 |
| immunofluorescence: 1:100-1:500 | |
| UniProt accession no. | P43220 |
| Application: | Anti-GLP1R antibody produced in rabbit has been used in immunofluorescence staining. |
| Biochem/physiol Actions: | Glucagon-like peptide 1 receptor (GLP1R) protein participates in the activation of protein kinase A (PKA), phosphoinositide 3-kinase (PI3K), MEK1/2, and endothelial nitric oxide synthase (eNOS) pathways. Hence, it plays a key role in apoptosis reduction, improved energy metabolism, decreased inflammation in myocardial cells, and vasodilation in myocardial arteries. The large N-terminal extracellular domain of GLP1R participates in ligand binding. Alterations in the GLP1R gene might increase the risk of coronary artery disease (CAD). |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-GLP1R Antibody detects endogenous levels of total GLP1R protein. |
| General description: | Glucagon-like peptide 1 receptor (GLP1R) protein belongs to the class B G protein-coupled receptor (GPCR) secretin family. This classic seven-transmembrane protein is abundantly expressed in the cardiovascular system. The GLP1R gene is located on the human chromosome 6p21. Anti-GLP1R Antibody detects endogenous levels of total GLP1R protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human GLP1R. Immunogen Range: 101-150 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |