Anti-GLUR2 antibody produced in rabbit
SIGMA/SAB4501295 - affinity isolated antibody
Synonym: GluR-2; GluR-B; GluR-K2; Glutamate receptor 2; Glutamate receptor ionotropic
Product Type: Chemical
Immunohistochemistry Anti-GLUR2: Cat. No. SAB4501295: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-GLUR2 antibody. Cells on the left were treated with the Anti-GLUR2 antibody. Cells on the right (negative control) were treated with both Anti-GLUR2 antibody and the synthesized immunogen peptide.
Western Blotting Anti-GLUR2: Cat. No. SAB4501295: Immunoblotting analysis of extracts from COLO205/HuvEC cells, using Anti-GLUR2 antibody. The lane on the left was treated with the Anti-GLUR2 antibody. The lane on the right (negative control) was treated with both Anti-GLUR2 antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 98 kDa |
| NCBI accession no. | P42262   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:20000 |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P42262 |
| Application: | Anti-GLUR2, C-Terminal antibody has been used in electron microscopy. |
| Biochem/physiol Actions: | Presence of the glutamate receptor 2 (GluR2) subunit prevents calcium influx through AMPA-receptor complexes. Deletion of this subunit results in enhanced hippocampal long-term potentiation. As such, AMPA receptors play crucial roles in normal neuronal activity, including synaptic plasticity, synaptic scaling, homeostatic synaptic plasticity, learning and memory, as well as in synaptogenesis and the formation of neuronal circuitry. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-GLUR2 Antibody detects endogenous levels of total GLUR2 protein. |
| General description: | GLUR2 (glutamate receptor 2) is coded by gria2 gene. It is mapped to human chromosome 4q32. It is abundantly expressed in the brain. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human GluR2. Immunogen Range: 834-883 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |