Anti-MGLUR2 antibody produced in rabbit
SIGMA/SAB4501318 - affinity isolated antibody
Synonym: GPRC1C; GRM3; MGR3; Metabotropic glutamate receptor 3 precursor; glutamate receptor
Product Type: Chemical
Immunohistochemistry Anti-MGLUR2: Cat. No. SAB4501318: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-MGLUR2 antibody. Cells on the left were treated with the Anti-MGLUR2 antibody. Cells on the right (negative control) were treated with both Anti-MGLUR2 antibody and the synthesized immunogen peptide.
Western Blotting Anti-MGLUR2: Cat. No. SAB4501318: Immunoblotting analysis of extracts from mouse brain cells, using Anti-MGLUR2 antibody. The lane on the left was treated with the Anti-MGLUR2 antibody. The lane on the right (negative control) was treated with both Anti-MGLUR2 antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 95 kDa |
| NCBI accession no. | Q14416   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:1000 |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | Q14416 |
| Biochem/physiol Actions: | Metabotropic glutamate receptor (MGLUR2) is involved in the glutamatergic system in the brain. Overexpression of glutamate in brain areas such as the prefrontal cortex, hippocampus and amygdala leads to anxiety and schizophrenia, activation of MGLUR2 in these areas reduces the excitatory neurotransmission, therefore mGlu2 receptor might be considered as a potential target for the treatment of these diseases. MGLUR2 signaling inhibits adenylyl cyclase (AC) activity. MGLUR2 is crucial in the modulation of synaptic transmission. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Metabotropic glutamate receptor 2 (MGLUR2) with 872 amino acid residues is encoded by the gene mapped to human chromosome 3. MGLUR2 belongs to the class c of G-protein-coupled receptor (GPCRs) family. It is expressed mainly in the central nervous system (CNS) of rat brain and widely expressed in human adult and fetal brain. MGLUR2 is characterized with an α-helical helix 8 (H8) domain. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human mGluR2/3. Immunogen Range: 823-872 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |