Anti-GRM2 antibody produced in rabbit
SIGMA/SAB4501319 - affinity isolated antibody
Synonym: GPRC1B; GRM2; MGLUR2; Metabotropic glutamate receptor 2; mGluR2
Product Type: Chemical
Immunohistochemistry Anti-GRM2: Cat. No. SAB4501319: Immunohistochemistry analysis of paraffin-embedded human brain tissue using Anti-GRM2 antibody. Cells on the left were treated with the Anti-GRM2 antibody. Cells on the right (negative control) were treated with both Anti-GRM2 antibody and the synthesized immunogen peptide.
Immunofluorescence Anti-GRM2: Cat. No. SAB4501319: Immunofluorescence of LOVO cells using Anti-GRM2 antibody. Cells on the left were treated with the Anti-GRM2 antibody. Cells on the right (negative control) were treated with both Anti-GRM2 antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 95 kDa |
| NCBI accession no. | Q14416   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, human, mouse |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:1000 |
| immunofluorescence: 1:100-1:500 | |
| immunohistochemistry: 1:50-1:100 | |
| UniProt accession no. | Q14416 |
| Biochem/physiol Actions: | Metabotropic glutamate receptor (MGLUR2) is involved in the glutamatergic system in the brain. Overexpression of glutamate in brain areas such as the prefrontal cortex, hippocampus and amygdala leads to anxiety and schizophrenia, activation of MGLUR2 in these areas reduces the excitatory neurotransmission, therefore mGlu2 receptor might be considered as a potential target for the treatment of these diseases. GRM2 signaling inhibits adenylyl cyclase (AC) activity. GRM2 is required for the modulation of synaptic transmission. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-GRM2 Antibody detects endogenous levels of total GRM2 protein. |
| General description: | Metabotropic glutamate receptor 2 (MGLUR2/GRM2) with 872 amino acids, is encoded by the gene mapped to human chromosome 3. GRM2 belongs to the class c of G-protein-coupled receptor (GPCRs) family. It is expressed mainly in the central nervous system (CNS) of rat brain and widely expressed in human adult and fetal brain. GRM2 is characterized with an α-helical helix 8 (H8) domain. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human GRM2. Immunogen Range: 241-290 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |