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Anti-Nuclear Receptor NR4A1 antibody produced in rabbit

SIGMA/SAB4501406 - affinity isolated antibody

Synonym: Early response protein NAK1; Nuclear receptor subfamily 4 group A member 1; Orphan nuclear receptor HMR; ST-59; TR3 orphan receptor

Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SAB4501406-100UG 100 µg
$560.00
1/EA
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Immunohistochemistry Anti-Nuclear Receptor NR4A1: Cat. No. SAB4501406: Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using Anti-Nuclear Receptor NR4A1 antibody. Cells on the left were treated with the Anti-Nuclear Receptor NR4A1 antibody. Cells on the right (negative control) were treated with both Anti-Nuclear Receptor NR4A1 antibody and the synthesized immunogen peptide.
Western Blotting Anti-Nuclear Receptor NR4A1: Cat. No. SAB4501406: Immunoblotting analysis of extracts from COS7 cells, using Anti-Nuclear Receptor NR4A1 antibody. The lane on the left was treated with the Anti-Nuclear Receptor NR4A1 antibody. The lane on the right (negative control) was treated with both Anti-Nuclear Receptor NR4A1 antibody and the synthesized immunogen peptide.

 

antibody form affinity isolated antibody
antibody product type primary antibodies
biological source rabbit
clone polyclonal
concentration ~1 mg/mL
conjugate unconjugated
form buffered aqueous solution
mol wt antigen 64 kDa
NCBI accession no. P22736 
Quality Level 100 
shipped in wet ice
species reactivity rat, human, mouse
storage temp. −20°C
target post-translational modification unmodified
technique(s) ELISA: 1:10000
  immunohistochemistry: 1:50-1:100
  western blot: 1:500-1:1000
UniProt accession no. P22736 
Biochem/physiol Actions: Nuclear receptor subfamily 4 group A member1 (NR4A1) participates in gene expression regulation in the hypothalamic-pituitary-adrenal axis (HPA) especially those related to inflammation and steroidogenesis. The levels of NR4A1 are downregulated in metastatic melanoma, myelogenous leukemia, and follicular thyroid carcinoma. An elevated expression of NR4A1 is observed in type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) in mouse models. Dysfunction of NR4A1 is correlated to energy balance and also the events of metabolic pathways including carbohydrates and lipids. NR4A1 contributes to arterial vessel cell wall damage. It regulates tumor cell proliferation, migration, and invasion. NR4A1 may serve as a biomarker for depression and other psychiatric disorders.
Disclaimer: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits: Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. 
General description: Nuclear receptor subfamily 4 group A member1 (NR4A1) is an orphan receptor that belongs to the nuclear hormone receptor superfamily. The NR4A1 gene is mapped to human chromosome 12q13.13. Structurally, NR4A1 comprises an N-terminal AB region, DNA binding domain (DBD), and a C-terminal ligand-binding domain (LBD). Anti-Nuclear Receptor NR4A1 antibody detects endogenous levels of total Nuclear Receptor NR4A1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from human Nuclear Receptor NR4A1.

Immunogen Range: 317-366
Physical form: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
RIDADR NONH for all modes of transport
WGK Germany nwg
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. −20°C
UNSPSC 12352203

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