Anti-JAK1 antibody produced in rabbit
SIGMA/SAB4501597 - affinity isolated antibody
Synonym: JAK-1; JAK1; JAK1A; Janus kinase 1; kinase Jak1
Product Type: Chemical
Immunohistochemistry Anti-JAK1: Cat. No. SAB4501597: Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Anti-JAK1 antibody. Cells on the left were treated with the Anti-JAK1 antibody. Cells on the right (negative control) were treated with both Anti-JAK1 antibody and the synthesized immunogen peptide.
Western Blotting Anti-JAK1: Cat. No. SAB4501597: Immunoblotting analysis of extracts from A549, using Anti-JAK1 antibody. The lane on the left was treated with the Anti-JAK1 antibody. The lane on the right (negative control) was treated with both Anti-JAK1 antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 131 kDa |
| NCBI accession no. | P23458   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:10000 |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P23458 |
| Biochem/physiol Actions: | Mutations in janus kinase 1 (JAK1) results in leukemia, breast cancer, lung cancer and HCC (hepatocellular carcinoma). It participates in signaling with many cytokines. JAK1 is also involved in the immune response and the initiation of allergic airway disease. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-JAK1 Antibody detects endogenous levels of total JAK1 protein. |
| General description: | Janus kinase 1 (JAK1) is a non-receptor tyrosine kinase, that belongs to the JAK family. It is located on human chromosome 1p31.3. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human JAK1. Immunogen Range: 988-1037 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |