Anti-MUC1 antibody produced in rabbit
SIGMA/SAB4501933 - affinity isolated antibody
Synonym: Breast carcinoma-associated antigen DF3; CD227; Carcinoma-associated mucin; EMA; Episialin
Product Type: Chemical
Immunohistochemistry Anti-MUC1: Cat. No. SAB4501933: Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Anti-MUC1 antibody. Cells on the left were treated with the Anti-MUC1 antibody. Cells on the right (negative control) were treated with both Anti-MUC1 antibody and the synthesized immunogen peptide.
Immunofluorescence Anti-MUC1: Cat. No. SAB4501933: Immunofluorescence of A549 cells using Anti-MUC1 antibody. Cells on the left were treated with the Anti-MUC1 antibody. Cells on the right (negative control) were treated with both Anti-MUC1 antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 122 kDa |
| NCBI accession no. | P15941   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:20000 |
| immunofluorescence: 1:100-1:500 | |
| immunohistochemistry: 1:50-1:100 | |
| UniProt accession no. | P15941 |
| Application: | Anti-MUC1, C-Terminal antibody produced in rabbit is suitable for immunohistochemistry and indirect immunofluorescence. |
| Biochem/physiol Actions: | MUC1 (Mucin 1) plays a major role in the formation of epithelium lining of the gastrointestinal tract. It lubricates the gastrointestinal tract, to protect the epithelia from oesophagus to the colon. It also lubricates the epithelia of some organs such as pancreas and gall bladder. It is directly involved in several signaling pathways as a modulator that affects oncogenesis, motility and metastasis. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-MUC1 Antibody detects endogenous levels of total MUC1 protein. |
| General description: | MUC1 (Mucin 1) is O-glycosylated, carbohydrate rich, transmembrane glycoprotein. It has approximately 13 members in the family. It is localized on the apical surface of mucosal epithelia in the lung, eye, breast and stomach. It is overexpressed in several epithelial cancers, including pancreatic ductal adenocarcinoma. It is a heterodimer consisting of N-terminal (MUC1-N) and C-terminal (MUC1-C) subunits. N-terminal (MUC1-N) end contains tandem repeats (VNTR) which forms the mucin component. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human MUC1. Immunogen Range: 1191-1240 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |