Anti-CFTR antibody produced in rabbit
SIGMA/SAB4501942 - affinity isolated antibody
Synonym: ABCC7; Cystic fibrosis transmembrane conductance regulator; cAMP- dependent chloride channel
MDL Number: MFCD01321917
Product Type: Chemical
Immunohistochemistry Anti-CFTR: Cat. No. SAB4501942: Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using Anti-CFTR antibody. Cells on the left were treated with the Anti-CFTR antibody. Cells on the right (negative control) were treated with both Anti-CFTR antibody and the synthesized immunogen peptide.
Western Blotting Anti-CFTR: Cat. No. SAB4501942: Immunoblotting analysis of extracts from NIH-3T3 cells, using Anti-CFTR antibody. The lane on the left was treated with the Anti-CFTR antibody. The lane on the right (negative control) was treated with both Anti-CFTR antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 168 kDa |
| NCBI accession no. | P13569   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:1000 |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P13569 |
| Application: | Anti-CFTR antibody produced in rabbit is suitable for immunohistochemistry and western blot applications. |
| Biochem/physiol Actions: | CFTR (Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette sub-family C, member 7) is mainly involved in the regulation of Na+ and Cl- transport by acting as a linear, cAMP activated, chloride channel. In addition, it is also associated with different transport signaling pathways. It has been reported that CFTR controls functionality of outwardly rectifying Cl- channels (ORCCs) by facilitating the transport and delivery of potent autacoid agonist and ORCC regulator ATP. It has also been suggested that CFTR can interact with Na+-reabsorptive pathway. CFTR is associated with congenital bilateral absence of the vas deferens (CBAVD) and causes the genital form of cystic fibrosis (CF). The CFTR gene may also responsible for male infertility. It may be useful for assisting reproduction technology. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-CFTR Antibody detects endogenous levels of total CFTR protein. |
| General description: | CFTR (Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette sub-family C, member 7) is a membrane-associated, N-linked glycoprotein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human CFTR. Immunogen Range: 711-760 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |