Anti-NRF2 antibody produced in rabbit
SIGMA/SAB4501984 - affinity isolated antibody
Synonym: HEBP1; NF-E2 related factor 2; NF2L2; NFE2-related factor 2; NFE2L2
Product Type: Chemical
Immunohistochemistry Anti-NRF2: Cat. No. SAB4501984: Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using Anti-NRF2 antibody. Cells on the left were treated with the Anti-NRF2 antibody. Cells on the right (negative control) were treated with both Anti-NRF2 antibody and the synthesized immunogen peptide.
Immunofluorescence Anti-NRF2: Cat. No. SAB4501984: Immunofluorescence of HuvEc cells using Anti-NRF2 antibody. Cells on the left were treated with the Anti-NRF2 antibody. Cells on the right (negative control) were treated with both Anti-NRF2 antibody and the synthesized immunogen peptide.
Western Blotting Anti-NRF2: Cat. No. SAB4501984: Immunoblotting analysis of extracts from HuvEc cells, using Anti-NRF2 antibody. The lane on the left was treated with the Anti-NRF2 antibody. The lane on the right (negative control) was treated with both Anti-NRF2 antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 67 kDa |
| NCBI accession no. | Q16236   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | rat, mouse, human |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:5000 |
| immunofluorescence: 1:100-1:500 | |
| immunohistochemistry: 1:50-1:100 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | Q16236 |
| Application: | Anti-NRF2, C-Terminal antibody produced in rabbit has been used in western blotting analysis. |
| Biochem/physiol Actions: | Nrf2 (nuclear factor, erythroid 2 like 2) is involved in the regulation of anti-oxidative and anti-inflammatory response. The protein encoded is a transcription factor that binds to the antioxidant response element of the target gene. In response to oxidative stress, Nrf2 upregulates the enzymes associated with detoxification, anti-inflammation, cytoprotection and antioxidative pathways. Nrf2 affects glucose metabolism and ROS (reactive oxygen species) homeostasis in cancer cells by regulating the pentose phosphate pathway. Thus, Nrf2 is known to contribute to the development of cancer by promoting cell proliferation. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | Anti-NRF2 Antibody detects endogenous levels of total NRF2 protein. |
| General description: | NRF2 (nuclear factor, erythroid 2 like 2) gene is mapped to human chromosome 2q31.2. The encoded protein is localized to dendritic cells. It belongs to the cap ′n′ collar (CNC) family of transcription factors. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human Nrf2. Immunogen Range: 556-605 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |