Anti-NPY2R antibody produced in rabbit
SIGMA/SAB4502029 - affinity isolated antibody
Synonym: NPY-Y2 receptor; NPY2-R; NPY2R; Neuropeptide Y receptor type 2
Product Type: Chemical
Immunofluorescence Anti-NPY2R: Cat. No. SAB4502029: Immunofluorescence of A549 cells using Anti-NPY2R antibody. Cells on the left were treated with the Anti-NPY2R antibody. Cells on the right (negative control) were treated with both Anti-NPY2R antibody and the synthesized immunogen peptide.
Western Blotting Anti-NPY2R: Cat. No. SAB4502029: Immunoblotting analysis of extracts from HepG2 cells, using Anti-NPY2R antibody. The lane on the left was treated with the Anti-NPY2R antibody. The lane on the right (negative control) was treated with both Anti-NPY2R antibody and the synthesized immunogen peptide.
| antibody form | affinity isolated antibody |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | polyclonal |
| concentration | ~1 mg/mL |
| conjugate | unconjugated |
| form | buffered aqueous solution |
| mol wt | antigen 42 kDa |
| NCBI accession no. | P49146   |
| Quality Level | 100 |
| shipped in | wet ice |
| species reactivity | human, mouse, rat |
| storage temp. | −20°C |
| target post-translational modification | unmodified |
| technique(s) | ELISA: 1:1000 |
| immunofluorescence: 1:100-1:500 | |
| western blot: 1:500-1:1000 | |
| UniProt accession no. | P49146 |
| Biochem/physiol Actions: | NPY2R (neuropeptide Y receptor Y2) acts as a presynaptic autoreceptor and heteroreceptor. It regulates the release of both endogenous NPY and neurotransmitters such as glutamate and γ–aminobutyric acid (GABA). NPY exerts its anxiolytic function via the NPY2R. Deletion of NPY2R results in retardation of the anticonvulsant actions of NPY. NPY2R plays an important role in the process of bone formation. |
| Disclaimer: | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
| Features and Benefits: | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| General description: | The NPY2R (neuropeptide Y receptor Y2) gene is mapped to human chromosome 4q32.1 and codes for a G-protein-coupled receptor. NPY2R is predominantly expressed in central nervous system including hypothalamus, brain stem, hippocampus, lateral septum and amygdala. NPY2 receptors are also distributed in the liver, spleen, intestine, adipose tissue and muscle. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from human NPY2R. Immunogen Range: 1-50 |
| Physical form: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | nwg |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352203 |